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작성자 Maxine
댓글 0건 조회 14회 작성일 25-09-14 02:33

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maxres.jpgGlycogen is too giant a molecule to be released and journey intercellularly. As well as it seems that glycogen’s role isn't to offer energy substrate purely for astrocytes, thus the trafficking of lactate to neural components is sensible, however does pose a number of essential questions. Initial research by Pierre Magistretti’s group investigated the role of neurotransmitters and different compounds in regulating the glycogen content material. They found that glycogen was certainly up- and down regulated by such compounds (Magistretti et al., 1993b, 1994; Sorg et al., 1995) and it was in the course of the investigation of how glutamate impacts glycogen content that the ANLSH scheme was uncovered (Pellerin and Magistretti, 1994). This labile property of glycogen makes practical sense because it means it can be up- and down regulated underneath variable physiological circumstances, as yet unknown, to satisfy key calls for. Studies by the Ransom laboratory used a special technique to check glycogen, using the rodent optic nerve as an experiential mannequin of central white matter (Stys et al., 1991). Some great benefits of this mannequin had been that it lacked synapses and neurotransmitters, being composed of cable like myelinated axons, astrocytes and oligodendrocytes (Ransom et al., 1990). As well as axon conduction may very well be recorded in real time, thus by judicious addition or subtraction of vitality substrates and other compounds within the aCSF that superfuses the tissue the position of key compounds may very well be investigated (Brown et al., 2001a, b).

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Any excess glucose that our body doesn’t actually need is transformed into glycogen by way of glycogenesis and stored in our muscles and liver. Much like a savings account in a financial institution shops the excess cash that we don’t necessarily have to spend in the mean time. The glycogen reserves are known as upon when we want additional power - glycogen is decomposed again into glucose via glycogenolysis and the cells in our body can then make use of the glucose to generate power once more. Now, each gram of stored glycogen pulls 3 grams of water with it. If we had been to devour more glucose than we need, we’d retailer it as glycogen, and stored glycogen additionally accumulates water - which may lead to water retention. Hence it's immediately apparent that a eating regimen rich in carbohydrates can promote water retention, and switching out some carbohydrates for other power sources corresponding to fats might help to cut down the water retention. Which does sound counter-intuitive.

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