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Understanding Circadian Balance
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Melatonin production begins with an antioxidant called serotonin. When the retinal cells in the retina of our eyes are stimulated by natural light, a signal is sent to the hypothalamus, the part of the brain responsible for regulating our basic needs. In response to light, the hypothalamus suppresses serotonin production, leading to a decrease in melatonin synthesis. Conversely, when it grows dark, the hypothalamus stimulates the production of serotonin in the pineal guardian official website gland, which is then changed into melatonin.
Melatonin is a hormone known for its wakefulness-preventing abilities. Animal studies have consistently shown that melatonin administration can sync up disrupted circadian rhythms, reducing sleep latency. While these results are often hailed as significant findings in sleep medicine, research on humans has yielded contradictory results.
In the human body, melatonin not only regulates sleep-wake cycles but also takes on other roles such as acting as an antioxidant, and participating in the pathogenesis of certain neurodegenerative diseases like Alzheimer's. Melatonin deficiency has been associated with several conditions including sleep disorders, but also some chronic diseases like fibromyalgia. Conversely, excessive melatonin is linked to several side effects including nausea, thus illustrating the fine balance required to maintain optimal melatonin production.
Studies have also shown a positive correlation between increased melatonin levels and its antioxidant properties. As an agent capable of absorbing oxidative species, and inducing mild cell death in some types of cancer cells, melatonin can offer an added layer of health protection by protecting the body from damage.
While research shows prospects in understanding the critical position of melatonin and the pineal gland in human health, further research is necessary to fully understand their intricacies.
Melatonin research has raised more concerns than answers about healthy melatonin amounts in older adults and how this changes in response to strain, daylight exposure, and eating schedule.
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